Driving Performance Related Tasks, B-Blockers and the new Antidepressants
The study was conducted as a double blind, placebo controlled, four-way cross over study. To assess the psychomotor effects of the administered drugs, the participants were required to perform the critical flicker fusion frequency task (CFF), choice reaction time task (CRT), Bond- Lader visual analogue scale of mood (VASM) and the digit-symbol substitution test (DSST). A significant effect between condition and time for CRT (F(3)= 7.918, p<0.001), CFF (F(3)= 2.459, p<0.05), and DSST(F(3)= 2.488, p<0.05) tests was found, which indicated that a decrement in psychomotor performance over time had occurred after concurrent administration of paroxetine and pindolol together. The explanation for the drug-drug interaction is not clear from this study, but may be due to one or more factors, such as a pharmacokinetic or pharmacodynamic interaction.
Download Complete Document: UniMelb_Norman_Oct01 [PDF: 87 KB]
Type: Research and Analysis Report
Sub Type: Grant
Author(s): Assoc Prof Trevor Norman
Publication Date: 01/10/01